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Related Experiment Videos

Neuroinformatics: a new tool for studying the brain.

Floyd E Bloom1, John H Morrison, Warren G Young

  • 1Neurome Inc., 11149 North Torrey Pines Road, La Jolla, CA 92037, USA. fbloom@neurome.com

Journal of Affective Disorders
|February 21, 2006
PubMed
Summary

Developing new methods to map gene expression in the mouse brain aids drug development for central nervous system diseases like Alzheimer's disease and Amyotrophic Lateral Sclerosis.

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Area of Science:

  • Neuroscience
  • Genomics
  • Drug Development

Background:

  • Central nervous system (CNS) diseases are a primary focus for pharmaceutical research and development.
  • The mammalian nervous system expresses a vast number of genes, presenting significant complexity for study.

Purpose of the Study:

  • To present improved methodologies for mapping gene expression patterns within the mouse brain.
  • To facilitate the evaluation of phenotypic changes in genetic models relevant to human brain disorders.

Main Methods:

  • Utilizing advanced techniques for gene expression mapping in the mouse brain.
  • Employing genetic models to study progressive phenotypic alterations.

Main Results:

  • Demonstrated utility of the described framework and methodology through studies on mouse models of Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's disease (AD).

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  • Highlighted the potential for data application in accelerating drug discovery for neurodegenerative conditions.

    • Conclusions:

    • The developed framework and methods can significantly aid drug development for CNS diseases.
    • Future applications may extend to research on affective disorders, given their overlap with symptoms seen in Alzheimer's disease, such as behavioral and emotional disturbances.