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[Acute pancreatitis--a free radical disease. Decrease in fatality with sodium selenite (Na2SeO3) therapy].

B Kuklinski1, M Buchner, R Schweder

  • 1Abteilung für Anästhesiologie und Intensivmedizin, Klinikums Rostock Süd.

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|April 1, 1991
PubMed
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Acute pancreatitis involves increased lipid peroxidation, indicated by malonic dialdehyde (MDA). Selenium therapy significantly reduced mortality and improved patient outcomes by enhancing antioxidant activity.

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Medical Research

Background:

  • Acute pancreatitis is associated with elevated malonic dialdehyde (MDA), an indicator of lipid peroxidation.
  • MDA levels correlate inversely with serum calcium and serve as a prognostic marker.
  • Acute pancreatitis is hypothesized to be a "free radical disease".

Purpose of the Study:

  • To investigate the efficacy of sodium selenite as an adjuvant therapy for acute necrotizing pancreatitis.
  • To evaluate the impact of selenium on lipid peroxidation markers and serum calcium levels.
  • To explore the mechanism of selenium's therapeutic effect in acute pancreatitis.

Main Methods:

  • A randomized clinical study involving patients with acute necrotizing pancreatitis.

Related Experiment Videos

  • Adjuvant therapy with daily 500 micrograms of sodium selenite.
  • Monitoring of malonic dialdehyde (MDA) and serum calcium levels.

    • Main Results:

    • The control group exhibited an 89% lethality rate, while no deaths occurred in the selenium therapy group.
    • Selenium therapy rapidly normalized serum calcium and decreased elevated MDA levels within 24 hours.
    • Selenium administration increased phospholipid-hydroperoxide-glutathione peroxidase activity.

    Conclusions:

    • Selenium therapy demonstrates a significant survival benefit in acute necrotizing pancreatitis.
    • Selenium effectively mitigates lipid peroxidation and restores calcium homeostasis.
    • The therapeutic effect of selenium is attributed to enhanced antioxidant enzyme activity, protecting cell membranes and modulating inflammatory pathways.