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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Androgen modulation of hippocampal synaptic plasticity

N J MacLusky1, T Hajszan, J Prange-Kiel

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA. nmaclusk@uoguelph.ca

Neuroscience
|February 21, 2006
PubMed
Summary

Androgens, like testosterone, are crucial for maintaining hippocampal structure and synaptic density in the brain. This neurotrophic effect is independent of estrogen in males but not females.

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