Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lobular involvement in human breast carcinoma.

H Ishige1, T Komatsu, Y Kondo

  • 1Second Department of Pathology, School of Medicine, Chiba University, Japan.

Acta Pathologica Japonica
|March 1, 1991
PubMed
Summary

Lobular involvement in breast carcinoma, identified in 43% of cases, precedes stromal invasion. This process begins with ductal extension and leads to lobular distortion and eventual invasion, highlighting terminal ductal-lobular units as key sites.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-life use of underwear treated with fabric softeners improves skin dryness by decreasing the friction of fabrics against the skin.

International journal of cosmetic science·2011
Same author

Increased E2F-1 expression via tumour cell proliferation and decreased apoptosis are correlated with adverse prognosis in patients with squamous cell carcinoma of the oesophagus.

Journal of clinical pathology·2005
Same author

Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation.

Molecular pathology : MP·2003
Same author

Prostate-specific antigen density adjusted for the transition zone for staging clinically localized prostate cancer in Japanese patients with intermediate serum prostate-specific antigen levels.

Anticancer research·2001
Same author

Malignant adenomyoepithelioma of the breast: a non-tubular and matrix-producing variant.

Pathology international·2001
Same author

Sialolipoma: a report of seven cases of a new variant of salivary gland lipoma.

Histopathology·2001

Area of Science:

  • Oncology
  • Pathology
  • Breast Cancer Research

Background:

  • Breast carcinoma exhibits diverse pathological patterns.
  • Understanding the early stages of tumor progression is crucial for diagnosis and treatment.
  • The role of lobular involvement in breast cancer invasion requires further clarification.

Purpose of the Study:

  • To investigate the occurrence and characteristics of lobular involvement in breast carcinoma.
  • To elucidate the relationship between lobular involvement and stromal invasion.
  • To classify patterns of lobular involvement and their association with tumor progression.

Main Methods:

  • Histopathological examination of 129 breast carcinoma cases.
  • Identification and classification of lobular involvement and intraductal carcinoma components.

Related Experiment Videos

  • Analysis of cellular changes, myoepithelial cell behavior, and basement membrane integrity.

    • Main Results:

    • Lobular involvement was observed in 56 cases (43%), characterized by extension from intralobular ducts.
    • Progressive involvement led to lobular distortion and loss of perilobular myoepithelial cells.
    • Stromal invasion originated from breaks in the basement membrane, often initiated by peripheral budding or focal necrosis.

    Conclusions:

    • Terminal ductal-lobular units are frequently involved in breast carcinomas.
    • Lobular involvement represents an early step in extraductal invasion.
    • Classifying lobular involvement may provide insights into different growth activities and invasion patterns.