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Related Experiment Videos

Diagnostic problems in tissues previously sampled by fine-needle aspiration.

S O Tabbara1, H F Frierson, R E Fechner

  • 1Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.

American Journal of Clinical Pathology
|July 1, 1991
PubMed
Summary

Fine-needle aspiration can cause unusual tissue changes, mimicking tumors like liposarcoma or carcinoma. Pathologists must recognize these post-procedure artifacts to avoid misdiagnosis in subsequent biopsies.

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Area of Science:

  • Pathology
  • Cytopathology
  • Surgical Pathology

Background:

  • Fine-needle aspiration (FNA) is a common diagnostic procedure.
  • Tissue alterations in needle tracts can occur post-FNA.
  • Accurate interpretation of biopsy specimens is crucial for patient management.

Observation:

  • Case 1: Mesenteric nodule with spindle cells and fat necrosis after FNA of a retroperitoneal mass.
  • Case 2: Breast needle tract with atypical epithelial cells mimicking carcinoma after FNA.

Findings:

  • The mesenteric nodule showed reactive myofibroblasts, not liposarcoma.
  • Breast needle tract cells were consistent with comedocarcinoma, not invasive carcinoma.
  • Both cases demonstrated post-FNA changes that could lead to diagnostic errors.

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Implications:

  • Needle tract changes can mimic neoplastic processes, posing diagnostic challenges.
  • Awareness of these changes is essential for correct interpretation of subsequent biopsies.
  • Careful correlation of cytologic and histologic findings is critical to avoid misdiagnosis.