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Updated: Aug 11, 2026
Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
Published on: August 11, 2023
Indocyanine green angiography features of Malattia leventinese
E H Souied1, N Leveziel, G Querques
1Clinique Ophtamologique Universitaire de Créteil, 40 Avenue de Verdun, 94010 Créteil, France. eric.souied@chicreteil.fr
Background/Aim:
Malattia leventinese (ML) is an inherited macular degeneration characterised by the presence of small radial drusen. Despite extensive descriptions of this study of the fundus, angiographic features of ML have been inadequately described. The aim is to describe the indocyanine green angiography (ICG) features observed in ML.
Methods:
10 eyes from five consecutive ML patients (aged 27-44 years) were prospectively included. A complete ophthalmological examination including colour fundus photographs, autofluorescence, fluorescein angiography (FA), and ICG was performed.
Results:
ICG differentiated two types of drusen. Large round aggregated drusen were consistently hypofluorescent in the early phases and presented as hyperfluorescent spots surrounded by halos of hypofluorescence in the late phases. Conversely, small radial drusen were mostly hyperfluorescent in the early phases with decreased fluorescence in the late phases of the ICG sequence. FA also showed differences in staining between the two types of drusen.
Conclusions:
ICG angiography revealed marked differences between the large round and small radial drusen observed in ML. The large central drusen presented with an unusual pustuliform feature on the late phases of the ICG sequence. This distinct feature may be useful in the diagnosis of late stage disease when drusen consolidation could obscure the radial drusen.
Insights
Indocyanine green angiography (ICG) revealed distinct features of drusen in Malattia leventinese (ML). Large round drusen showed unique pustuliform changes in late phases, aiding diagnosis in advanced stages.
Area of Science:
- Ophthalmology
- Medical Imaging
- Genetics
Background:
- Malattia leventinese (ML) is an inherited macular degeneration.
- Characterized by small radial drusen, its angiographic features are poorly understood.
- This study focuses on indocyanine green angiography (ICG) in ML.
Purpose of the Study:
- To describe the indocyanine green angiography (ICG) features in Malattia leventinese (ML).
- To differentiate between drusen types using ICG.
- To identify diagnostic markers for ML.
Main Methods:
- Prospective study of 10 eyes from five consecutive ML patients (aged 27-44).
- Ophthalmological examination including color fundus photography, autofluorescence, fluorescein angiography (FA), and ICG.
- Analysis of ICG sequences for drusen characteristics.
Main Results:
- ICG differentiated two drusen types: large round and small radial.
- Large round drusen were hypofluorescent early, becoming hyperfluorescent with hypofluorescent halos late.
- Small radial drusen were hyperfluorescent early, with decreased fluorescence late.
Conclusions:
- ICG angiography highlights significant differences between large round and small radial drusen in ML.
- Large central drusen exhibited a pustuliform appearance in late ICG phases.
- This distinct feature aids in diagnosing late-stage ML where drusen consolidation may obscure radial drusen.
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