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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Drug-eluting stent-supported percutaneous coronary intervention for chronic total coronary occlusion
Angela Migliorini1, Guia Moschi, Ruben Vergara
1Division of Cardiology, Careggi Hospital, Florence, Italy.
Insights
Drug-eluting stents (DES) significantly reduce restenosis and major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI) for chronic total coronary occlusion (CTO). However, longer stents and small vessels remain risk factors for restenosis.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomedical Engineering
Background:
- Limited data exist on the effectiveness of drug-eluting stents (DES) for percutaneous coronary intervention (PCI) in chronic total coronary occlusion (CTO).
- This study addresses the efficacy of DES in CTO by comparing outcomes with bare metal stents (BMS).
Purpose of the Study:
- To evaluate the clinical and angiographic outcomes of DES-supported PCI in patients with CTO.
- To compare the efficacy of DES versus BMS in treating CTO.
Main Methods:
- A retrospective analysis of consecutive patients undergoing DES implantation for CTO (sirolimus- or paclitaxel-eluting stents).
- Comparison with a case-matched control group treated with BMS prior to routine DES use.
- Assessment of clinical and angiographic outcomes at 6 months and 12 months.
Main Results:
- Successful DES-supported PCI was achieved in 92 patients (104 CTOs), compared to 26 patients (27 CTOs) treated with BMS.
- The 6-month major adverse cardiac event (MACE) rate was lower in the DES group (9.8%) versus the BMS group (23%) (P=0.072).
- The 6-month restenosis rate was significantly lower with DES (19%) compared to BMS (45%) (P<0.001).
Conclusions:
- DES implantation for CTO effectively reduces mid-term restenosis and MACE.
- Implantation of long stents or treatment of small vessels (<2.5 mm) in CTO remains associated with a higher risk of restenosis.
Objectives:
This study sought to determine the clinical and angiographic outcomes after drug-eluting stent (DES)-supported percutaneous coronary intervention (PCI) for chronic total coronary occlusion (CTO).
Background:
There are few data about the efficacy of DES-supported PCI for CTO.
Methods:
All consecutive patients who had a sirolimus-eluting stent or a paclitaxel-eluting stent implanted for CTO from December 2003 to December 2004 were analyzed. Clinical and angiographic outcomes of patients treated with DES were compared with a case-matched control group of patients treated with bare metal stents (BMS) in the 12 months before the routine use of DES.
Results:
Successful DES-supported PCI was performed in 92 patients and 104 CTO. The case-matched control group consisted of 26 patients and 27 CTO successfully treated with BMS. There were no differences between groups in baseline clinical and angiographic characteristics. Stent length in the DES group was higher as compared with that of BMS group (51+/-28 mm vs. 40+/-19 mm, P=0.073). The 6-month major adverse cardiac event (MACE) rate was lower in the DES group as compared with that of BMS group (9.8% vs. 23%, P=0.072). The angiographic follow-rate was 80% in the DES group and 81% in the BMS group. The 6-month restenosis rate was 19% in the DES group and 45% in the BMS group (P<0.001). By multivariate analysis, it was found that in the DES group, the only predictors of restenosis were stented segment length (OR 1.031, 95% CI 1.01-1.06, P=0.009) and a target vessel reference diameter<2.5 mm (OR 6.48, 95% CI 1.51-27.83, P=0.012), while the only predictor of MACE was stent length (OR 1.04, 95% CI 1.01-1.08, P=0.006).
Conclusions:
DES implantation for CTO decreases the risk of mid-term restenosis and MACE. Small vessels and diffuse disease requiring the implantation of multiple stents and very long stents for full coverage of the target lesion are still associated with a relatively high risk of restenosis.
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