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Related Experiment Videos

Circulating adrenomedullin in obstructive sleep apnoea.

Richard Schulz1, Christiane Flötotto, Andreas Jahn

  • 1Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, Justus-Liebig-University, Giessen, Germany. richard.schulz@innere.med.uni-giessen.de

Journal of Sleep Research
|February 24, 2006
PubMed
Summary

Obstructive sleep apnea (OSA) patients show elevated adrenomedullin (AM) levels, a vasodilator. Continuous positive airway pressure (CPAP) therapy significantly reduces these levels, suggesting AM

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Area of Science:

  • Cardiovascular Physiology
  • Sleep Medicine
  • Endocrinology

Background:

  • Adrenomedullin (AM) is an endothelial-derived vasodilator.
  • Stimuli like hypoxia and cytokines, present in obstructive sleep apnea (OSA), may increase AM production.
  • Vascular dysfunction is a concern in OSA patients.

Purpose of the Study:

  • To investigate whether vascular adrenomedullin (AM) production is increased in patients with obstructive sleep apnea (OSA).
  • To assess the effect of continuous positive airway pressure (CPAP) therapy on plasma AM levels in OSA patients.

Main Methods:

  • Plasma AM levels were measured using an enzyme immunoassay kit in 41 OSA patients and 28 controls.
  • Blood samples were collected after polysomnography and at follow-up points during CPAP therapy.

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  • Patients were matched for anthropometric and comorbid factors.

    • Main Results:

    • Untreated OSA patients exhibited significantly higher plasma AM concentrations compared to controls.
    • AM levels did not differ between normotensive and hypertensive OSA patients.
    • Two nights of CPAP therapy led to a significant decrease in AM levels, with normalization after long-term use.

    Conclusions:

    • Circulating AM is elevated in untreated OSA, independent of hypertension.
    • CPAP therapy effectively reduces elevated AM levels in OSA patients.
    • AM upregulation may be an adaptive response to mitigate cardiovascular risks associated with OSA.