Related Experiment Video
Updated: Aug 11, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
Published on: September 4, 2015
Selective stabilization and synaptic specificity: a new cell-biological model
James D Jontes1, Greg R Phillips
1Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, 115 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA.
Abstract:
How are appropriate connections between neurons sorted from the overwhelming surplus of potential, yet inappropriate, connections? Despite the apparently improbable nature of the process, brains wire themselves with a high degree of reproducibility that has been conserved across evolutionary history. Here, we outline a viable cell-biological model for generating synaptic specificity that features selection of nascent synapses based on adhesion and recognition. This process uses the highly dynamic and stochastic nature of intracellular trafficking to generate reproducible patterns of synaptic connectivity.
More Related Videos
07:51Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
Published on: November 14, 2014
08:30Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
Published on: September 17, 2011
Related Concept Videos
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Determination