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Biomarkers of OH radical damage in vivo
L R Karam1, D S Bergtold, M G Simic
1Center for Radiation Research, National Institute of Standards and Technology, Gaithersburg, MD 20899.
Free Radical Research Communications
|January 1, 1991
Abstract:
Mechanisms of formation of o-tyrosine (o-Tyr) and thymine glycol (TG), the two possible markers of OH radical generation in biosystems and in vivo are described. The o-Tyr measurements require invasive approaches, while TG detection may be accomplished by noninvasive analysis in the urine.