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Related Experiment Video

Updated: Jul 10, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 16, 2010

Endothelium-derived epoxyeicosatrienoic acids and vascular function.

Ingrid Fleming¹, Rudi Busse

¹Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany. fleming@em.uni-frankfurt.de

Hypertension (Dallas, Tex. : 1979)

|February 24, 2006

Summary

Epoxyeicosatrienoic acids (EETs) are crucial signaling molecules in blood vessels. This review highlights their role in vasodilation and promoting new blood vessel growth (angiogenesis).

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Last Updated: Jul 10, 2026

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Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Published on: June 28, 2019

Area of Science:

Biochemistry
Molecular Biology
Vascular Biology

Background:

Epoxyeicosatrienoic acids (EETs) are lipid mediators derived from arachidonic acid.
They are synthesized by cytochrome P450 (CYP) epoxygenases.

Purpose of the Study:

To review the role of CYP-derived EETs in endothelium-derived hyperpolarizing factor (EDHF)-mediated responses.
To highlight EETs' function as second messengers in endothelial cell signaling pathways involved in angiogenesis.

Main Methods:

Literature review of studies on EETs, CYP epoxygenases, and endothelial cell function.
Analysis of evidence for EETs' involvement in vasodilation and angiogenesis.

Main Results:

CYP epoxygenase activation in endothelial cells contributes to NO and prostacyclin-independent vasodilation.
EETs act as EDHF and have membrane potential-independent effects.
EETs modulate signaling cascades influencing endothelial cell proliferation and angiogenesis.

Conclusions:

CYP-derived EETs play a significant role in EDHF-mediated vascular responses.
EETs are vital second messengers in endothelial cell signaling pathways regulating angiogenesis.