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Magnetic resonance evaluation of the cerebral circulation in obstructive arterial disease

Peter Jan van Laar1, Jeroen van der Grond, Willem P T M Mali

  • 1Department of Radiology, University Medical Center, Utrecht, The Netherlands. p.j.vanlaar@azu.nl

Cerebrovascular Diseases (Basel, Switzerland)
|February 24, 2006
PubMed

Insights

Magnetic resonance imaging (MRI) offers comprehensive assessment of obstructive arterial disease by evaluating cerebral circulation anatomy and hemodynamics. Advanced MRI techniques provide detailed insights into brain blood flow, distribution, and perfusion.

Area of Science:

  • Neuroimaging
  • Vascular Medicine
  • Radiology

Background:

  • Obstructive arterial disease impacts cerebral circulation.
  • Assessing both anatomic and hemodynamic aspects is crucial for understanding brain hemodynamic changes.

Purpose of the Study:

  • To highlight the capabilities of magnetic resonance imaging (MRI) in evaluating patients with obstructive arterial disease.
  • To analyze the anatomic and hemodynamic aspects of extra- and intracranial cerebral circulation.

Main Methods:

  • Utilized contrast-enhanced, time-of-flight, and phase contrast MR angiography (MRA) for arterial anatomy.
  • Employed 2D phase contrast MRA for evaluating hemodynamics at levels 1 and 2.
  • Applied dynamic MRA to visualize Circle of Willis blood distribution.
  • Used dynamic susceptibility contrast MRI and arterial spin labeling (ASL) MRI for regional brain perfusion (level 3).

Main Results:

  • Distinguished three levels of cerebral circulation: blood flow, distribution, and perfusion.
  • Demonstrated MRA's ability to visualize neck arteries and the Circle of Willis.
  • Showcased ASL MRI's capacity to assess perfused territories of individual brain-feeding arteries.

Conclusions:

  • Current MR techniques enable a comprehensive 20-minute evaluation of cerebral circulation from the aortic arch to brain tissue perfusion.
  • Combined MR methods can clarify pathophysiological relationships between vasculature, perfusion, and brain function in steno-occlusive disease.
Abstract

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