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Adherence to aspirin in secondary prevention of ischemic stroke

Aida Lago1, Jose Ignacio Tembl, Ana Pareja

  • 1Department of Neurology, La Fe University Hospital, Valencia, Spain. alagom@meditex.es

Cerebrovascular Diseases (Basel, Switzerland)
|February 24, 2006
PubMed

Insights

Aspirin adherence in ischemic stroke patients was excellent, with over 90% compliance. This study confirms that personal interviews and biochemical tests effectively assess patient adherence to antiplatelet therapy.

Area of Science:

  • Neurology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Antiplatelet therapy, particularly aspirin, is crucial for secondary stroke prevention.
  • Assessing patient adherence to long-term medication is vital for treatment efficacy.

Purpose of the Study:

  • To evaluate adherence to aspirin treatment in patients with a history of ischemic stroke.
  • To determine the effectiveness of personal interviews and biochemical markers in assessing aspirin compliance.

Main Methods:

  • A study involving outpatients from 5 neurological centers in Valencia with a history of ischemic stroke and at least 6 months of aspirin therapy.
  • Data collection included personal interviews regarding treatment adherence and biochemical assessment of platelet thromboxane A2 synthesis.

Main Results:

  • Out of 73 patients, 66 (90.4%) underwent laboratory tests.
  • All tested patients demonstrated inhibition of thromboxane A2 synthesis, indicating aspirin intake.
  • Excellent aspirin compliance was observed, with at least 90% adherence even when considering non-attendees for lab tests.

Conclusions:

  • Aspirin compliance in ischemic stroke patients is excellent.
  • The combination of personal interviews and biochemical assessment of platelet thromboxane A2 synthesis is an adequate method for evaluating adherence.
  • Findings align with existing literature on antiplatelet therapy adherence.
Abstract

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