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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Mapping Normal And Cancer Cell Signalling Networks: Towards Single-cell Proteomics.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Mapping Normal And Cancer Cell Signalling Networks: Towards Single-cell Proteomics.

    • Related Experiment Videos

    Mapping normal and cancer cell signalling networks: towards single-cell proteomics.

    Jonathan M Irish1, Nikesh Kotecha, Garry P Nolan

    • 1Department of Medicine, Oncology Division, Stanford University, Stanford, California 94305, USA.

    Nature Reviews. Cancer
    |February 24, 2006

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Single-cell proteomics analyzes cell signaling in individual cancer cells to understand tumor progression. This approach identifies therapeutic targets and biomarkers for improved cancer diagnosis and patient prognosis.

    Related Experiment Videos

    Area of Science:

    • Cancer Biology
    • Proteomics
    • Cell Signaling

    Background:

    • Oncogenesis and tumor progression are driven by altered cell signaling pathways.
    • Understanding these signaling alterations at a single-cell level is crucial for effective cancer treatment.

    Approach:

    • Flow cytometry enables the analysis of signaling events within individual cancer cells.
    • This data facilitates the construction of cell-specific signaling network maps.

    Key Points:

    • Single-cell proteomics links specific signaling profiles to clinical outcomes.
    • Identifies signaling pathways active in therapy-resistant cancer cells.
    • Potential for discovering novel biomarkers for cancer diagnosis and prognosis.

    Conclusions:

    • Single-cell proteomics offers a powerful tool for dissecting cancer cell signaling.
    • Enables the identification of predictive biomarkers and therapeutic targets for personalized cancer medicine.