Appetite regulatory peptides in Indian Antarctic expeditioners

Antarctica presents an inhospitable environment due to extreme low temperature, high wind velocity, low humidity, snowstorms, long polar days and nights, high level of UV radiations, magnetic storms and increased ionisation along with social isolation and sexual deprivation. Acclimatisation to any new condition is associated with certain metabolic changes along with alteration in nutritional requirements. There are reports of increased food intake and gain in body weight during past Indian Antarctic expeditions. Therefore, the present study was undertaken with the aim to assess the changes in appetite regulatory peptides i.e. leptin and neuropeptide Y in relation to energy intake and expenditure of the Antarctic expeditioners. The study was conducted in three phases viz. Phase I at Goa (basal), Phase II 48 h after reaching Antarctica and Phase III after one month of stay at Antarctica. Energy and nutrient intake were analysed from the duplicate plate samples of the expeditioners. Energy expenditure was computed using 24 h activity records for 7 days. Blood samples were collected in each phase for biochemical estimations. After reaching Antarctica, the expeditioners were active and the total energy expenditure (mean +/- SEM, n = 10) was found to be 3120 +/- 474 kcal/day. The actual energy intake was found to be 3911 +/- 310 kcal/day. This indicates that the Antarctic expeditioners had very active life and weight gain during expedition could be due to positive energy balance. After 48 h of stay at Antarctica plasma leptin levels (mean +/- SEM, n = 22) decreased from normal basal values 5.66 (+/- 0.59) ng/ml (Phase I) to 4.40 (+/- 0.37) ng/ml (Phase II), even though there was an increase in body fat. Increased level of plasma leptin was observed in Phase III as compared to phase I and II. Concomitantly there was increase in plasma neuropeptide Y levels from 0.303 (+/- 0.004) ng/ml to 1.211 (+/- 0. 27) ng/ml (p < 0.001) in Phase II and decrease in Phase III. The decrease in plasma leptin levels and increase in neuropeptide Y levels in Phase II may be responsible for increase in appetite and gain in body weight at Antarctica.