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Updated: Aug 11, 2026

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
Published on: June 19, 2015
Versatile precursors of functional RAFT agents. Application to the synthesis of bio-related end-functionalized
Maël Bathfield1, Franck D'Agosto, Roger Spitz
1Unité Mixte CNRS-bioMérieux, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, France.
Abstract:
Biomolecule-polymer conjugates are widely used in bio-related fields, but their synthesis is often tricky, especially the introduction of a single biomolecule at one chain end. This paper describes a new straightforward approach to prepare such conjugates via RAFT polymerization. By designing appropriate bio-related RAFT agents, polymer chains of controlled chain length (Mn = 10 000-40 000 and PDI < 1.1) carrying a single biomolecule as an alpha-end group (a sugar or a biotin) linked by a stable amide bond are obtained. Considering the versatility of the RAFT process, this strategy appears to be very attractive for the design of a variety of conjugates.
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