Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Overcoming roadblocks in lead optimization: a thermodynamic perspective

Adam J Ruben¹, Yoshiaki Kiso, Ernesto Freire

¹Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

Chemical Biology & Drug Design

|February 24, 2006

Summary

No abstract available in PubMed .

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Extrapolating differential scanning calorimetry data for monoclonal antibodies to low temperatures.

Analytical biochemistry·2024

Same author

Development of high-affinity nanobodies specific for Na<sub>V</sub>1.4 and Na<sub>V</sub>1.5 voltage-gated sodium channel isoforms.

The Journal of biological chemistry·2022

Same author

Reversibility and irreversibility in the temperature denaturation of monoclonal antibodies.

Analytical biochemistry·2021

Same author

Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2-Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages.

International journal of molecular sciences·2021

Same author

Binding Thermodynamics to Intrinsically Disordered Protein Domains.

Methods in molecular biology (Clifton, N.J.)·2020

Same author

Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors.

Tetrahedron·2020