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Difficult asthma.

¹Section of Pulmonary and Critical Care Medicine, Department of Medicine, Committee on Clinical Pharmacology and Pharmacogenetics, University of Chicago, Chicago, Illinois 60637, USA. mstrek@medicine.bsd.uchicago.edu

Proceedings of the American Thoracic Society

|February 24, 2006

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Managing difficult-to-control asthma requires a systematic approach. Identifying triggers and considering alternative diagnoses are crucial steps for effective asthma management and improved patient outcomes.

Area of Science:

Pulmonology
Allergy and Immunology
Pharmacology

Background:

Asthma is typically diagnosed and treated easily, but 5% of patients have difficult-to-control disease.
These patients require a rigorous diagnostic and treatment strategy.

Purpose of the Study:

To outline a systematic approach for diagnosing and treating therapy-resistant asthma.
To discuss potential triggers, optimal medical therapies, and emerging treatment strategies.

Main Methods:

Review of diagnostic criteria and differential diagnoses for asthma.
Evaluation of triggers contributing to asthma exacerbations.
Assessment of current and emerging pharmacologic treatments for difficult asthma.

Main Results:

Related Experiment Videos

Accurate diagnosis and trigger identification are paramount.
High-dose inhaled corticosteroids and long-acting beta(2)-agonists are standard, often with oral corticosteroids.
Combination inhalers may improve compliance; leukotriene modifiers and anti-IgE antibodies show promise.

Conclusions:

Therapy-resistant asthma necessitates a comprehensive evaluation to confirm diagnosis and eliminate triggers.
Personalized treatment based on identified phenotypes may optimize outcomes and prevent overmedication.
Further research into asthma phenotypes is essential for tailored therapeutic strategies.