Advances in computer-aided diagnosis for breast cancer

Computer-aided diagnosis (CAD) is a technology used for the detection and characterization of cancer. Although CAD is not limited to a single type of cancer, a large number of CAD systems to date have been designed and used for breast cancer. The aim of this review is to discuss the current state of the CAD systems for breast-cancer diagnosis, their application as a second reader in clinical practice, and studies that have evaluated the effect of CAD on radiologists' performance.

A large number of CAD applications are being developed for different imaging modalities. Owing to commercially available Food and Drug Administration (FDA) approved systems, the main clinical use of CAD to date is for screen-film mammography. Many studies have shown that CAD improves radiologists' performance. A large number of academic institutions have devoted a substantial research effort to developing CAD methods.

CAD systems will play an increasingly important role in the clinic as a second reader. Clinical trials have shown that CAD can improve the accuracy of breast-cancer detection. Preclinical studies have demonstrated the potential of CAD to improve the classification of malignant and benign lesions. An increased number of CAD systems are being developed for different breast-imaging modalities.