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Combinatorial roles of nuclear receptors in inflammation and immunity

Christopher K Glass1, Sumito Ogawa

  • 1Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. ckg@ucsd.edu

Nature Reviews. Immunology
|February 24, 2006
PubMed

Insights

Nuclear receptors like peroxisome-proliferator-activated receptors (PPARs) and liver X receptors (LXRs) regulate immune responses. These receptors, along with the glucocorticoid receptor, work together to manage inflammation in the body.

Area of Science:

  • Immunology
  • Molecular Biology
  • Endocrinology

Background:

  • Nuclear receptors, including PPARs and LXRs, are known to influence inflammatory processes.
  • Recent research implicates PPARs and LXRs in regulating gene expression in immune cells like macrophages and lymphocytes.

Purpose of the Study:

  • To explore the regulatory roles of PPARs and LXRs in innate and adaptive immunity.
  • To understand how these nuclear receptors interact with transcription factors and signaling pathways to modulate immune responses.

Main Methods:

  • Review of recent studies on nuclear receptor function in immunity.
  • Analysis of interactions between PPARs, LXRs, and other signaling systems.

Main Results:

  • PPARs and LXRs play significant roles in both innate and adaptive immunity.
  • These receptors interact with transcription factors and cellular signaling pathways to control immune gene expression.
  • PPARs and LXRs demonstrate combinatorial action with the glucocorticoid receptor.

Conclusions:

  • PPARs and LXRs are key regulators of immune responses.
  • Combinatorial mechanisms involving PPARs, LXRs, and glucocorticoid receptor integrate inflammatory signals.
  • These nuclear receptors offer potential therapeutic targets for managing inflammatory conditions.

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