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Related Experiment Videos

ETS transcription factor ER81 is required for the Pacinian corpuscle development.

J Sedý1, S Tseng, J M Walro

  • 1Institute of Anatomy, First Faculty of Medicine, Charles University, U nemocnice 3, 128-00 Prague, Czech Republic.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|February 24, 2006
PubMed
Summary

The transcription factor ER81 is essential for developing Pacinian corpuscles, a type of mechanoreceptor. Without ER81, these sensory structures and their associated nerve fibers fail to form or survive.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • ER81 (ETS family transcription factor) plays roles in neuronal identity and muscle spindle development.
  • ER81 expression is observed in the inner core cells of Pacinian corpuscles.

Purpose of the Study:

  • To investigate the role of ER81 in the development of Pacinian corpuscles, a class of mechanoreceptors.

Main Methods:

  • Analysis of Er81 null mice and Er81(+/lacZ) mutants.
  • Embryonic analysis at E16.5.
  • Assessment of Pacinian corpuscle and afferent nerve fiber presence.
  • Evaluation of calretinin-expressing dorsal root ganglia neurons.

Main Results:

  • Er81 null mice lack Pacinian corpuscles and their afferent nerve fibers at birth.

Related Experiment Videos

  • Embryonic analysis revealed absence of corpuscles but presence of afferents at E16.5.
  • Deficiency in calretinin-positive neurons correlated with the absence of corpuscles and afferents.

    • Conclusions:

    • ER81 is required for the proper assembly of Pacinian corpuscles.
    • ER81 is crucial for the survival of sensory neurons innervating Pacinian corpuscles.