Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A multidimensional proteomic approach to identify hypertrophy-associated proteins.

Merry L Lindsey1, Danielle K Goshorn, Susana Comte-Walters

  • 1Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA. lindseym@uthscsa.edu

Proteomics
|February 24, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Engineering Perspective on the Importance of Obtaining Operational Stability in Graduate School.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same author

Bugs as drugs: parasite biomolecules as novel therapeutics against breast cancer.

American journal of physiology. Cell physiology·2026
Same author

Cellular and molecular signals of cardiac wound healing after myocardial infarction.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Comprehensive evaluation of plasma biomarkers in patients with abdominal aortic aneurysm using high-throughput, label-free quantitative proteomic profiling.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.

Critical care (London, England)·2025
Same author

Multi-omics Integration with GWAS Unveils Molecular Mechanistic Insights for Type 2 Diabetes.

bioRxiv : the preprint server for biology·2025

Researchers identified 123 proteins involved in left ventricular hypertrophy (LVH), a key factor in heart failure. This proteomic analysis offers new insights into cardiac growth mechanisms and potential therapeutic targets for LVH.

Area of Science:

  • Cardiovascular Biology
  • Proteomics
  • Molecular Cardiology

Background:

  • Left ventricular hypertrophy (LVH) is a major precursor to congestive heart failure.
  • The precise molecular mechanisms driving cardiac hypertrophy and its progression to failure remain incompletely understood.
  • A comprehensive understanding of the protein landscape in LVH is crucial for elucidating these mechanisms.

Purpose of the Study:

  • To investigate the proteomic alterations associated with left ventricular hypertrophy (LVH).
  • To identify known and novel proteins implicated in the development and progression of pressure-induced cardiac hypertrophy.
  • To provide a detailed protein inventory for future research into LVH pathogenesis.

Main Methods:

  • Utilized the transverse aortic constriction (TAC) mouse model to induce pressure overload and LVH.

Related Experiment Videos

  • Employed a multidimensional proteomic approach for comprehensive protein identification and quantification.
  • Integrated various proteomic techniques to ensure a robust and thorough analysis.

    • Main Results:

    • Identified 123 differentially expressed proteins in the hypertrophied left ventricle.
    • Key identified proteins include LIM proteins, thioredoxin, myoglobin, fatty acid binding protein 3, ASPM, actin, and myosin.
    • Discovered several proteins with previously unknown functions in the context of LVH, opening new research avenues.

    Conclusions:

    • The study provides a significant expansion of the known proteome associated with LVH.
    • The identified proteins offer potential targets for understanding and treating heart failure progression.
    • The multidimensional proteomic strategy enhances our understanding of the molecular basis of cardiac hypertrophy.