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(-)-N,N'-but-2-ene-1,4-diylbimorphinans
H Schmidhammer1, C F Smith, E Dalkner
1Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Austria.
Die Pharmazie
|February 1, 1991
Abstract:
N,N'-But-2-ene-1,4-diylbimorphinans 1-3 have been synthesized and pharmacologically evaluated. Bimorphinans 1 and 3 show opioid antagonist activity and preference for mu and kappa opioid receptors in mouse vas deferens and guinea pig ileum preparations.