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[A study on the methylation and glutathione S-transferases P1 activity in hepatocellular carcinoma tissues]

You-cai Zhang1, Yong-ping Chen, Jin-xia Chen

  • 1Department of Infectious Diseases, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China. zhangyc0815@163.com

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|February 24, 2006
PubMed
Abstract

No abstract available in PubMed .

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Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...

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