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Variable hormonogenesis in Cushing's syndrome.

M S Shapiro¹, L Shenkman

¹Endocrine Unit, Meir General Hospital, Kfar Saba, Israel.

The Quarterly Journal of Medicine

|April 1, 1991

Summary

This summary is machine-generated.

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Cyclic Cushing's syndrome involves fluctuating cortisol levels, presenting with varied symptoms and durations. Early identification is crucial, as standard tests may be normal between cycles.

Area of Science:

Endocrinology
Internal Medicine

Background:

Cushing's syndrome results from prolonged exposure to high cortisol levels.
Cyclic Cushing's syndrome is a rare variant characterized by intermittent hormonal hypersecretion.

Observation:

This study reviewed 44 cases of cyclic Cushing's syndrome, categorizing them by hormonal secretion patterns and clinical course.
Observed cycle lengths ranged from 12 hours to 85 days, persisting for up to 25 years.
Clinical manifestations were diverse, from isolated symptoms like edema to complex syndromes.

Findings:

Etiologies included pituitary-dependent Cushing's, corticotropin-producing tumors, adrenal hyperplasia, and other adrenal or hypothalamic disorders.
Biochemical patterns could be complex, and pituitary function might appear normal during intercyclic phases.

Related Experiment Videos

Inconsistent dexamethasone suppression test responses can indicate cyclic Cushing's syndrome.

Implications:

Highlights the diagnostic challenges of cyclic Cushing's syndrome, especially during intercyclic periods.
Emphasizes the need for serial monitoring and considering cyclic patterns in ambiguous cases.
Suggests that inconsistent dexamethasone suppression test results are a key diagnostic clue.