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[Changes in cyclooxygenase gene expression during spontaneous recovery from stress ulcer in rats]
Jun Xu1, Yu-gang Song, Xian-fu Sang
1Department of Emergency, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xzy1996@fimmu.com
Objective:
To observe the changes in gene expression of cyclooxygenase (COX) during spontaneous recovery from stress ulcer in rats exposed to water immersion and restraint stress (WRS).
Methods:
A rat model of stress ulcer was established by means of WRS, in which the changes in COX expression were detected with immunohistochemistry and reverse transcription (RT)-PCR.
Results:
Very low levels of COX-2 expression were detected in the gastric mucosa of the control rats, and the expression increased significantly during the healing process of the stress ulcer (P<0.05). COX-1 expression in the gastric mucosa showed no significant difference between the control group and the stress ulcer groups during healing (P>0.05).
Conclusion:
COX-1 and COX-2 expressions in rat gastric mucosa during the recovery from stress ulcer participate in the recovery of the damaged mucosa possibly by mediating prostaglandin secretion.
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