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Published on: October 25, 2013

Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate

Longzhu Cui1, Eiji Tominaga, Hui-Min Neoh

  • 1Department of Bacteriology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, Japan 113-8421. longzhu@med.juntendo.ac.jp

Antimicrobial Agents and Chemotherapy
|February 24, 2006
PubMed

Insights

Reduced daptomycin susceptibility strongly correlates with vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). A thickened cell wall likely contributes to this daptomycin resistance in S. aureus.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Staphylococcus aureus is a common cause of infections.
  • Vancomycin resistance in S. aureus is a growing concern.
  • Vancomycin-intermediate S. aureus (VISA) strains exhibit reduced susceptibility to vancomycin.

Purpose of the Study:

  • To investigate the correlation between daptomycin susceptibility and vancomycin resistance in VISA.
  • To explore the underlying mechanisms contributing to daptomycin resistance in VISA.

Main Methods:

  • Analysis of daptomycin susceptibility testing in VISA isolates.
  • Assessment of cell wall thickness in relation to antibiotic resistance.

Main Results:

  • A strong positive correlation was observed between reduced daptomycin susceptibility and vancomycin resistance in VISA.
  • Cell wall thickening was identified as a key factor associated with this correlation.

Conclusions:

  • Thickened cell walls in VISA may act as a physical barrier, contributing to daptomycin resistance.
  • Understanding this mechanism is crucial for developing effective treatment strategies against resistant S. aureus infections.

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