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Related Experiment Videos

Exercise training attenuates acute doxorubicin-induced cardiac dysfunction.

Adam J Chicco1, Carole M Schneider, Reid Hayward

  • 1School of Sport and Exercise Science and the Rocky Mountain Cancer Rehabilitation Institute University of Northern Colorado, Greeley, Colorado 80639, USA.

Journal of Cardiovascular Pharmacology
|February 24, 2006
PubMed
Summary

Chronic exercise training before doxorubicin treatment preserves cardiac function and reduces oxidative stress. Exercise protects against doxorubicin-induced heart dysfunction and increases heat shock protein-72 expression.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Exercise Physiology

Background:

  • Doxorubicin is an effective antitumor antibiotic.
  • Doxorubicin's clinical use is limited by dose-dependent cardiotoxicity.
  • Myocardial oxidative stress contributes to doxorubicin-induced cardiotoxicity.

Purpose of the Study:

  • To determine if chronic exercise training (ET) before doxorubicin treatment can preserve cardiac function.
  • To investigate if ET can reduce myocardial oxidative stress following doxorubicin administration.
  • To assess the impact of pre-treatment exercise on doxorubicin's effects on the heart.

Main Methods:

  • Rats underwent 12 weeks of either treadmill exercise or sedentary confinement.
  • Animals received intraperitoneal injections of doxorubicin (15 mg/kg) or saline.

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  • Cardiac function was assessed via Langendorff perfusion, followed by biochemical analyses.

    • Main Results:

    • Doxorubicin induced cardiac dysfunction, reduced coronary flow, and increased lipid peroxidation in sedentary rats.
    • Doxorubicin decreased manganese superoxide dismutase and increased heat shock protein-72 (Hsp72) expression.
    • Exercise training attenuated doxorubicin-induced cardiac dysfunction and lipid peroxidation, and increased Hsp72 expression.

    Conclusions:

    • Chronic exercise training prior to doxorubicin treatment protects against subsequent cardiac dysfunction.
    • Exercise training demonstrates a protective effect against doxorubicin-induced myocardial oxidative stress.
    • Pre-treatment exercise leads to sustained increases in myocardial Hsp72, potentially mediating cardioprotection.