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Updated: Aug 11, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
[Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives]
Li-mei Gao1, Peng Yang, Dan-qing Song
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Aim:
To design and synthesize new compounds of prandial glucose regulator with more simple structure.
Methods:
The target compounds were synthesized from diethyl succinate and benzaldehyde or 4-fluorobenzaldehyde by four-step reactions. Thus 18 compounds were synthesized. Their structures were comfirmed by NMR, MS and IR.
Results:
Seventeen compounds had different hypoglycemic activity in mice, among them, 9 compounds had higher hypoglycemic activity and 6 compounds had character of prandial glucose regulator.
Conclusion:
Part of the compounds have higher hypoglycemic activity deserve to be further investigated.
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