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Hypocalcaemia following therapy of thyrotoxicosis in an infant

Sonal Kansra1, Devidayal, Deepti Suri

  • 1Department of Paediatrics, Advanced Paediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. devbijaya@yahoo.co.in

Acta Paediatrica (Oslo, Norway : 1992)
|February 25, 2006
PubMed

Insights

Antithyroid drugs can cause severe hypocalcaemia in infants with thyrotoxicosis. Physicians should monitor calcium levels closely during treatment for this rare but serious complication.

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Medicine
  • Pharmacology

Background:

  • Graves' disease in mothers can affect newborns.
  • Infants with thyrotoxicosis may require antithyroid drug treatment.
  • Antithyroid medications are standard for managing neonatal thyrotoxicosis.

Observation:

  • A 2-month-old infant with thyrotoxicosis developed severe hypocalcaemia after starting antithyroid drugs.
  • Treatment required high-dose calcium infusions.
  • Elevated serum alkaline phosphatase and parathormone levels were noted.

Findings:

  • Initiation of antithyroid therapy in infants with thyrotoxicosis can lead to severe hypocalcaemia.
  • This complication is rare but potentially life-threatening.
  • Monitoring calcium levels is crucial during treatment.

Implications:

  • Alerts physicians to a rare complication of antithyroid therapy in infants.
  • Highlights the need for vigilant monitoring of calcium levels in neonates with thyrotoxicosis.
  • May influence treatment protocols for neonatal thyrotoxicosis.
Abstract

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