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Consistent expression of HGF and c-met in the perinatal lung

P Lassus1, J Janer, C Haglund

  • 1Department of Gastroenterological Surgery, Hospital for Children and Adolescents, Helsinki, Finland. patrik.lassus@helsinki.fi

Biology of the Neonate
|February 25, 2006
PubMed

Insights

Hepatocyte growth factor (HGF) and its receptor c-met are consistently expressed in the developing human lung. This supports HGF

Area of Science:

  • Pulmonary Medicine
  • Developmental Biology
  • Cell Biology

Background:

  • Hepatocyte growth factor (HGF) is an epithelial cell mitogen crucial for lung development and repair.
  • Lower pulmonary HGF levels in preterm infants correlate with increased respiratory disease severity.

Purpose of the Study:

  • To investigate the protein expression of HGF and its receptor c-met in the human lung during the perinatal period.

Main Methods:

  • Immunohistochemistry was used to detect HGF and c-met.
  • Lung tissues were analyzed from fetuses, preterm infants, term infants, and infants with bronchopulmonary dysplasia.

Main Results:

  • HGF was found in mesenchymal cells, bronchial, and distal airway epithelium.
  • c-met was detected in bronchial and distal airway epithelium, and in neutrophils.

Conclusions:

  • Consistent perinatal expression of HGF and c-met supports a physiological role in human lung development.
Abstract

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