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[Lipomatous meningioma: two case reports].

Taoufiq Harmouch1, Magali Colombat, Aida El Amri

  • 1Service d'Anatomie et de Cytologie Pathologiques, Hôpital Beaujon, 100 Boulevard du Général Leclerc, 92118 Clichy Cedex.

Annales De Pathologie
|February 25, 2006
PubMed
Summary

Lipomatous meningiomas, a rare WHO-classified tumor, show varied fat content. Immunohistochemistry suggests lipid accumulation is a meningothelial cell transformation, not metaplasia.

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Radiology

Background:

  • Lipomatous meningiomas are rare metaplastic tumors within the World Health Organization (WHO) classification.
  • This study presents two distinct cases of lipomatous meningiomas.

Observation:

  • Presenting symptoms included headaches and seizures.
  • Radiological findings were unique, with one tumor showing significant fat accumulation and the other resembling a conventional meningioma.
  • Microscopic examination revealed meningothelial and transitional meningiomas with varying adipose tissue, composed of mature adipocytes or lipoblasts.

Findings:

  • High and moderate fat content correlated with radiological appearances.
  • Immunohistochemical analysis showed expression of epithelial membrane antigen and progesterone receptors in all cell types, including lipid-accumulating cells.

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  • Lipid accumulation appears to be a transformation of meningothelial cells.

    • Implications:

    • This finding challenges the traditional view of lipomatous meningiomas as true metaplasia.
    • Understanding the cellular origin of lipid accumulation is crucial for accurate diagnosis and classification.
    • Further research into meningioma cell plasticity and differentiation is warranted.