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Intestinal permeability and diabetes mellitus type 2.
M Secondulfo1, L de Magistris, A Sapone
1Department F. Magrassi, Second University (SUN), Naples.
Minerva Gastroenterologica E Dietologica
|February 25, 2006
Summary
Type 2 diabetes does not appear to alter intestinal permeability, unlike type 1 diabetes. The Cellobiose/Mannitol test showed normal gut barrier function in patients with type 2 diabetes mellitus.
Area of Science:
- Gastroenterology
- Endocrinology
- Diabetology
Background:
- Intestinal permeability, assessed by molecular probes crossing villi and crypt tight junctions, is often altered in type 1 diabetes.
- This alteration in type 1 diabetes is linked to increased absorption of smaller probes.
Purpose of the Study:
- To investigate whether type 2 diabetes mellitus also affects intestinal permeability.
- To compare intestinal permeability in type 2 diabetes patients with healthy controls.
Main Methods:
- The Cellobiose/Mannitol (CE/MA) test was employed to evaluate intestinal permeability.
- The CE/MA test measures the passage of larger (Cellobiose) and smaller (Mannitol) probes across crypt and villi tight junctions, respectively.
- The test was administered to 18 type 2 diabetes patients and 25 healthy volunteers.
Main Results:
- Intestinal permeability was found to be normal in all type 2 diabetes patients studied.
- Key permeability parameters (%CE, %MA, CE/MA) were comparable to those of the control group.
- No statistically significant differences in intestinal permeability were observed between the groups.
Conclusions:
- The findings suggest that type 2 diabetes lacks specific pathophysiological intestinal components.
- This contrasts with type 1 diabetes, which is known to be associated with autoimmune conditions and celiac disease.
- Type 2 diabetes does not appear to impact gut barrier function as measured by the CE/MA test.