[Cofactor-antiphospholipid antibodies relationship in patients with systemic lupus erythematosus and infertility...

High frequency of detecting antiphospholipid antibodies (APA) is typical for patients with systemic autoimmune diseases as well as infertility women irresponsive to IVF treatment. Antiphospholipid antibodies cause thrombotic complications in patients with systemic autoimmune diseases contrary to antiphospholipid antibodies with in-vitro fertilization taken place. The authors have compared specificity and cofactor-antiphospholipid antibodies relationship in patient with systemic lupus erythematosus, infertility women irresponsive to IVF treatment and patients with chronic virus hepatitis. It has been shown that 80% of patients with systemic lupus erythematosus are mostly beta2-glycoprotein- and cofactor dependant. Patients with chronic virus hepatitis and women with in-vitro fertilization (IVF) have been found to have pretty low beta2-glycoprotein dependant antiphospholipid antibodies. Antiphospholipid antibodies in in-vitro fertilization women were cofactor dependant only in 28%. of the cases. These data can explain absence of thrombotic complication in APA positive IVF patient, because its complications have been associated with cofactor-dependent APA. It also can explain a lot of controversial results about significance of APA on IVF result.