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Related Experiment Videos

[Pharmacodynamical study on Danqi capsule].

Fu-huo Wu1, Xue-mei Liu, Ru Jia

  • 1Dept of Pharmacy, Fujian College of Traditional Chinese Medicine, Fuzhou, China. wufuhuo@163.com

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|February 28, 2006
PubMed
Summary
This summary is machine-generated.

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Danqi capsule effectively improves heart function, increases oxygen deficiency tolerance, and reduces pain and blood fat. It demonstrates superior efficacy compared to Danqi tablet at lower doses.

Area of Science:

  • Pharmacology
  • Traditional Chinese Medicine
  • Cardiovascular Research

Context:

  • Danqi capsule is a traditional Chinese medicine used for cardiovascular and pain conditions.
  • Its efficacy in promoting blood circulation and removing blood stasis is clinically recognized.

Purpose:

  • To evaluate the pharmacodynamic effects of Danqi capsule.
  • To compare its efficacy against Danqi tablet in various animal models.

Summary:

  • Danqi capsule improved electrocardiogram (ECG) in rats with myocardial ischemia and prolonged survival in hypoxic mice.
  • It significantly reduced pain responses in acetic acid-induced and uterospasm models.
  • The capsule lowered triglyceride and total cholesterol while increasing HDL-c in hyperlipidemic rats.

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  • Hemorheological parameters, including blood viscosity and erythrocyte rigidity, were significantly improved.

    • Impact:

    • Provides scientific evidence for the traditional uses of Danqi capsule.
    • Highlights its potential in treating myocardial ischemia, hypoxia, pain, and hyperlipidemia.
    • Suggests Danqi capsule may be a more potent and efficient alternative to Danqi tablet.