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Updated: Aug 11, 2026
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
[Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln[ (Phen)2 (5-Fu)3 (NO3) (NO3
Wen-yuan Zhong1, Zhi-xing Hu, Shun-fang Chen
1Kunming Teachers College, Kunming 650031, China.
Aim:
To study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs.
Methods:
A series of rare earth complexes were synthesized with Ln(NO3) 6H2O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods.
Results:
The formula of complex Ln[(Phen)2(5-Fu)3(NO3)](NO3)2(Ln = Y, La, Ce, Sm, Gd, Dy, Er; Phen = 1, 10-phenanthroline; 5-Fu = fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and 13C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro.
Conclusion:
The complex might have anti-tumor cooperation action.
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