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Updated: Aug 11, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors

Lawrence R Boone1

  • 1GlaxoSmithKline, Discovery Virology, Research Triangle Park, NC 27709, USA. larry.r.boone@gsk.com

Current Opinion in Investigational Drugs (London, England : 2000)
|February 28, 2006
PubMed
Summary

Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are advancing, with TMC-125 and TMC-278 showing promise for treatment-experienced patients. BILR-355 BS is in early trials, while others face discontinuation.

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