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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity
Emmanoel V Costa1, Maria Lúcia B Pinheiro, Clahildek M Xavier
1Departamento de Química, Universidade Federal do Amazonas, Avenida Gen. Rodrigo Otavio Jordão Ramos, 3000, Coroado, CEP 69077-000 Manaus, Amazonas, Brazil.
Abstract:
Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-beta-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was established on the basis of extensive 1D and 2D NMR and MS analyses. This is the third reported pyrimidine-beta-carboline-type alkaloid and is particularly important for Annona genus chemotaxonomy. In addition, all compounds exhibit in vitro antileishmanial activity against promastigote forms of Leishmania braziliensis. Compounds 2 and 4 showed better activity than compounds 1 and 3 against L. braziliensis. Compound 2 was not active against L. guyanensis.
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