Early transient leg swelling at the side of renal transplant in two children
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Updated: Aug 11, 2026

Murine Kidney Transplant Technique
Published on: October 20, 2015
L Koster-Kamphuis1, C E Die, J A der Vliet
1Department of Paediatrics, University Medical Centre St Radboud, Nijmegen, The Netherlands.
Insights
Leg swelling after renal transplantation in children can occur due to iliac vein compression and fluid collection, not thrombosis. Anticoagulation is recommended, but aggressive treatment should be avoided.
Area of Science:
- Pediatric Nephrology
- Surgical Complications
- Vascular Surgery
Background:
- Renal transplantation is a life-saving procedure for children with end-stage renal disease.
- Post-operative complications can impact graft function and patient well-being.
- Understanding rare complications is crucial for optimal patient management.
Observation:
- Two pediatric patients developed significant leg swelling adjacent to the renal transplant site.
- The swelling was attributed to extrinsic compression of the iliac vein by the transplanted kidney and surrounding fluid collection.
- Doppler flow studies were essential in ruling out deep vein thrombosis.
Findings:
- The leg swelling was a mechanical complication secondary to the renal transplant and fluid accumulation.
- Thrombosis was excluded as the cause of the swelling.
- Conservative management combined with anticoagulation proved effective.
Implications:
- This case highlights a rare but manageable complication following pediatric renal transplantation.
- Non-invasive imaging like Doppler ultrasound is vital for accurate diagnosis.
- Judicious use of anticoagulation, avoiding aggressive interventions, is key for favorable outcomes.
Abstract:
Two children are described with a huge leg swelling shortly after renal transplantation. The swelling was located at the side of the renal transplant. The swelling was caused by the compression of the iliac vein by the renal transplant combined with perirenal fluid collection. Doppler flow studies allow the exclusion of thrombosis as an explanation for the swelling. An aggressive treatment should be avoided. However, anticoagulation is required.
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