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Related Experiment Videos

Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression:

Y Dwivedi1, H S Rizavi, G N Pandey

  • 1Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA. ydwivedi@psych.uic.edu

Neuroscience
|February 28, 2006
PubMed
Summary

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Antidepressants can reverse stress-induced decreases in brain-derived neurotrophic factor (BDNF) expression in rats, but different drug classes affect specific BDNF exons uniquely. This highlights varied mechanisms in antidepressant action and stress response.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Brain-derived neurotrophic factor (BDNF) is implicated in stress and antidepressant mechanisms.
  • Antidepressants generally upregulate BDNF, while corticosterone (a stress hormone) downregulates it.
  • The specific effects of different antidepressant classes on corticosterone-mediated BDNF downregulation are not fully understood.

Purpose of the Study:

  • To investigate how various antidepressant classes (fluoxetine, desipramine, phenelzine) and corticosterone affect BDNF mRNA expression in rat brain.
  • To determine if antidepressants can reverse corticosterone-induced downregulation of BDNF.
  • To elucidate the differential regulation of BDNF exons by antidepressants and corticosterone.

Main Methods:

  • Rats were treated with corticosterone pellets to induce stress or left untreated.

Related Experiment Videos

  • Rats received daily injections of fluoxetine, desipramine, or phenelzine for 21 days.
  • BDNF mRNA levels, including specific exons (I-IV), were measured in the frontal cortex and hippocampus.

    • Main Results:

    • Corticosterone decreased total BDNF mRNA, specifically exons II and IV.
    • Desipramine and phenelzine reversed corticosterone-induced BDNF decrease in both brain regions.
    • Fluoxetine only partially reversed the decrease in the hippocampus, and different antidepressants modulated specific BDNF exons uniquely.

    Conclusions:

    • Both corticosterone and antidepressants modulate BDNF expression, with antidepressants reversing stress-induced decreases.
    • Different antidepressant classes exhibit distinct patterns of BDNF exon regulation.
    • These findings suggest varied molecular mechanisms underlying antidepressant efficacy and stress response.