Functional metabolic heart impairment after acute lethal hemorrhage followed by resuscitation

Effects of acute lethal blood loss on postresuscitation heart impairment has been studied. Experiments were performed in mongrel male rats anesthesized with sodium pentobarbital (25 mg/kg). Functional metabolic heart impairments have been evaluated in different terms after resuscitation by isolated perfused heart method (Fallen et al., J. Appl. Physiol, 22 (1967) 836-839). It has been established that maximal heart injury occurs in the first hours after resuscitation. It is supported by the following findings: depression of myocardium contractile function grew; enzyme excretion from cardiomyocytes in coronary flow increased: efficacy of glucose utilization by means of carried function decreased; pyruvate excretion in coronary flow elevated. Because of severe course of postresuscitation period functional metabolic heart disturbances are more pronounced and preserved for a long time.