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Related Experiment Videos

Cortical activation during menopausal hot flashes.

Robert R Freedman1, Mark D Benton, Richard J Genik

  • 1Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA. aa2613@wayne.edu

Fertility and Sterility
|February 28, 2006
PubMed
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Brain imaging reveals insula and anterior cingulate cortex activation during menopausal hot flashes. Thermoregulation involves a distributed brain network, not a single area.

Area of Science:

  • Neuroimaging
  • Human Physiology
  • Women's Health

Background:

  • Menopausal hot flashes are a common vasomotor symptom.
  • The neural basis of hot flashes and associated sweating remains incompletely understood.

Purpose of the Study:

  • To identify brain regions activated during menopausal hot flashes.
  • To investigate brain activation associated with sweating in women.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to measure brain activity.
  • The study included symptomatic postmenopausal women and asymptomatic eumenorrheic women.

Main Results:

  • Hot flashes in symptomatic women showed significant activation in the insula and anterior cingulate cortex (P<.001).

Related Experiment Videos

  • Sweating in eumenorrheic women was associated with activation in the anterior cingulate and superior frontal gyrus (P<.001).

    • Conclusions:

    • Insular cortex activation correlates with the sensation of heat during hot flashes.
    • Human thermoregulation appears to be managed by a widespread cortico-subcortical network.