Related Experiment Video

Updated: Aug 11, 2026

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

High-sensitivity C-reactive protein and parameters of left ventricular dysfunction

Sanjiv J Shah1, Gregory M Marcus, Ivor L Gerber

  • 1Division of Cardiology, Department of Medicine, University of California, San Francisco, 94143, USA.

Journal of Cardiac Failure
|February 28, 2006
PubMed

Insights

Elevated C-reactive protein (CRP) indicates inflammation and is linked to heart failure. Left ventricular end-diastolic pressure (LVEDP) is the clinical parameter most closely associated with higher CRP levels in patients.

Area of Science:

  • Cardiology
  • Inflammation Markers

Background:

  • Elevated high-sensitivity C-reactive protein (CRP) is linked to heart failure.
  • The specific parameters of left ventricular dysfunction correlating with CRP are unclear.

Purpose of the Study:

  • To investigate the correlation between clinical indices of left ventricular dysfunction and CRP levels.
  • To identify which left ventricular dysfunction parameters are most associated with elevated CRP.

Main Methods:

  • Cross-sectional study of 98 patients undergoing cardiac catheterization.
  • Analysis of CRP levels in relation to clinical parameters, including diabetes mellitus, heart failure, B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), and left-ventricular end-diastolic pressure (LVEDP).

Main Results:

  • CRP levels were significantly higher in patients with diabetes mellitus and heart failure.
  • Increased CRP correlated with higher BNP, lower LVEF, and higher LVEDP.
  • Multivariable analysis confirmed an independent association between LVEDP and CRP.

Conclusions:

  • CRP is elevated in heart failure patients.
  • Left-ventricular end-diastolic pressure (LVEDP) is the primary clinical parameter of left ventricular dysfunction associated with CRP levels.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...