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High-sensitivity C-reactive protein and parameters of left ventricular dysfunction.
Sanjiv J Shah1, Gregory M Marcus, Ivor L Gerber
1Division of Cardiology, Department of Medicine, University of California, San Francisco, 94143, USA.
Journal of Cardiac Failure
|February 28, 2006
Summary
Elevated C-reactive protein (CRP) indicates inflammation and is linked to heart failure. Left ventricular end-diastolic pressure (LVEDP) is the clinical parameter most closely associated with higher CRP levels in patients.
Area of Science:
- Cardiology
- Inflammation Markers
Background:
- Elevated high-sensitivity C-reactive protein (CRP) is linked to heart failure.
- The specific parameters of left ventricular dysfunction correlating with CRP are unclear.
Purpose of the Study:
- To investigate the correlation between clinical indices of left ventricular dysfunction and CRP levels.
- To identify which left ventricular dysfunction parameters are most associated with elevated CRP.
Main Methods:
- Cross-sectional study of 98 patients undergoing cardiac catheterization.
- Analysis of CRP levels in relation to clinical parameters, including diabetes mellitus, heart failure, B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), and left-ventricular end-diastolic pressure (LVEDP).
Main Results:
- CRP levels were significantly higher in patients with diabetes mellitus and heart failure.
- Increased CRP correlated with higher BNP, lower LVEF, and higher LVEDP.
- Multivariable analysis confirmed an independent association between LVEDP and CRP.
Conclusions:
- CRP is elevated in heart failure patients.
- Left-ventricular end-diastolic pressure (LVEDP) is the primary clinical parameter of left ventricular dysfunction associated with CRP levels.