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Related Experiment Videos

CD3+, CD4-, CD8- large granular T-cell lymphoproliferative disorder.

T Sun1, N S Cohen, J Marino

  • 1Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.

American Journal of Hematology
|July 1, 1991
PubMed
Summary

This study identifies a rare CD3+, CD4-, CD8- phenotype in large granular T-cell lymphoproliferative disorder (LGTLD). This unique LGTLD subtype shows a benign clinical course, suggesting distinct diagnostic and treatment approaches.

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Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Large granular T-cell lymphoproliferative disorder (LGTLD) is a heterogeneous group of diseases.
  • Most LGTLD cases exhibit a suppressor (CD8+) phenotype.
  • Further classification of LGTLD is necessary for accurate diagnosis and management.

Observation:

  • Two cases of CD3+, CD4-, CD8- LGTLD were identified.
  • These cases presented with persistent lymphocytosis but a benign clinical course.
  • No chemotherapy was required for either case.

Findings:

  • The CD3+, CD4-, CD8- phenotype expresses the T-cell receptor (TcR) gamma chain gene.
  • Terminal deoxynucleotidyl transferase negativity suggests a peripheral T-cell origin.
  • This phenotype represents a small subset (approx. 2%) of normal peripheral T-cells.

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Implications:

  • The CD3+, CD4-, CD8- phenotype represents a distinct LGTLD subtype.
  • This subtype appears to have a favorable prognosis.
  • Characterization using specific monoclonal antibodies and cytochemical stains is crucial.