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Related Experiment Videos

Bifenthrin activates homotypic aggregation in human T-cell lines.

Nataly Hoffman1, Van Tran, Anthony Daniyan

  • 1Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530, USA.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|February 28, 2006
PubMed
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Low-level exposure to bifenthrin pesticide may harm the immune system by activating T-cell function. This pesticide stimulates cell aggregation, potentially increasing the risk of inflammatory diseases like asthma.

Area of Science:

  • Immunology
  • Environmental Health
  • Toxicology

Background:

  • Concerns exist regarding potential immune system harm from low-level bifenthrin exposure, a common household pyrethroid pesticide.
  • This study investigated the effects of bifenthrin on human T-cell lines, specifically focusing on immune cell aggregation.

Purpose of the Study:

  • To determine if bifenthrin exposure, even at non-toxic levels, affects T-cell function.
  • To investigate the mechanism by which bifenthrin might impact immune responses, particularly cell aggregation.

Main Methods:

  • Human T-cell lines (H9, Jurkat) and a promonocyte cell line (U937) were exposed to varying bifenthrin concentrations.
  • Cell viability was assessed, and non-toxic concentrations were used to study phytohemagglutinin (PHA)-mediated homotypic aggregation.

Related Experiment Videos

  • Antibodies targeting ICAM and LFA-1 were employed to block and analyze aggregation pathways.

    • Main Results:

    • Bifenthrin was found to be non-toxic at concentrations between 10(-4) M and 10(-13) M.
    • While not inhibiting PHA-induced aggregation, bifenthrin (at 10(-4) M) stimulated homotypic aggregation in H9 and Jurkat cells.
    • This bifenthrin-induced aggregation was blocked by antibodies to LFA-1 and ICAM, similar to PHA-induced aggregation.

    Conclusions:

    • Bifenthrin activates T-cell function through ICAM/LFA-1 mediated homotypic aggregation.
    • Exposure to bifenthrin, even within acceptable limits, may elevate the risk and frequency of inflammatory conditions, including asthma.