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Published on: January 28, 2021

Lipoprotein(a) and lipid profile in patients with atrial fibrillation

José Antonio Díaz-Peromingo1, Ana Albán-Salgado, Florinda García-Suárez

  • 1Department of Internal Medicine, Hospital Da Barbanza, Riveira, Spain. jadiazperomingo@mundo-r.com

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|February 28, 2006
PubMed

Insights

This study found no significant difference in lipoprotein(a) levels between patients with atrial fibrillation (AF) and controls. The COL/HDL index was higher in AF patients, suggesting potential lipid profile alterations beyond Lp(a).

Area of Science:

  • Cardiology
  • Lipidology
  • Biochemistry

Background:

  • Atrial fibrillation (AF) is a known risk factor for embolic events, particularly cerebrovascular events.
  • Previous research has explored associations between AF and various lipid markers.
  • Lipoprotein(a) [Lp(a)] has been specifically investigated for its potential role in AF.

Purpose of the Study:

  • To investigate the lipid profile characteristics in patients diagnosed with atrial fibrillation.
  • To specifically evaluate and compare lipoprotein(a) [Lp(a)] levels in AF patients versus a control group.

Main Methods:

  • A case-control study involving 101 patients with AF and 101 matched controls.
  • Measurement of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and Lp(a).
  • Calculation of lipid indices: LDL/HDL, COL/LDL, and COL/HDL.

Main Results:

  • A statistically significant difference was observed in the COL/HDL index, which was higher in the AF patient group.
  • No statistically significant difference was found in lipoprotein(a) [Lp(a)] levels between patients with AF and the control group.
  • Other measured lipid markers and indices did not show significant differences between the groups.

Conclusions:

  • The study did not find a relationship between atrial fibrillation (AF) and elevated lipoprotein(a) [Lp(a)] levels in the studied Caucasian population.
  • Ethnic variations may contribute to differing findings compared to studies in other populations.
  • Further research is needed to elucidate the complex interplay between AF, lipid profiles, and genetic factors.
Abstract

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