[Eradicating therapy of Helicobacter pylori in the duodenal ulcer]

Helicobacter pylori (HP) is the conclusive etiopathogenetic element of peptic lesion. The disappearance of the bacteria from the antral mucosa involves a rapid cicatrization of the ulcer with correlated recidivist, in direct manner, to reinfections or insufficient treatments. The leading problem lies in definitive bacterial eradication, made difficult by the notable resistance of the HP to the antimicrobic agent. The therapeutic solutions require the contemporary use of medicine with a different mechanism of action. A triple medicine scheme has been experimented, with non-contemporary administration of Azithromycin and subsequently of metronidazol for 3 days and a tablet/day of omeprazolo for 30 days. The research was carried out on a sample of 60 units, affected by duodenal ulcer in active phase, with endoscopic and hystologic controls at the beginning and follow up at 60 days. The results show a bacterial eradication which exceed 90%, with regression of the symptomatology in 48-72 hours and side effects of modest entity. The collaboration of the subjects, after informed consent, was total, also favoured by the brevity of the cycle, uniformity of the dosing and easy distribution/day. The data confirm the etiopathogenetic value of the HP in the gastric and duodenal ulcer.