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Updated: Aug 11, 2026
Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
Published on: March 5, 2019
Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes
John K Fraser1, Ronda Schreiber, Brian Strem
1Cytori Therapeutics Inc., San Diego, CA, USA. jfraserconsulting@sbcglobal.net
Insights
Human adipose tissue offers a promising source for adult stem cells, potentially restoring cardiac function after ischemia. These cells show cardiomyocytic and endothelial differentiation, supporting cardiac cell therapy applications.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Stem Cell Biology
Background:
- Adult stem cells show potential for restoring cardiac function post-ischemia.
- Current therapies utilize autologous cells like myoblasts, blood, or bone marrow cells.
- Human adipose tissue presents an alternative cell source for cardiac repair.
Purpose of the Study:
- To investigate the potential of human adipose tissue-derived cells for cardiac cell therapy.
- To evaluate the differentiation capacity and therapeutic factors within adipose tissue cells.
Main Methods:
- Analysis of cells isolated from human adipose tissue.
- Assessment of differentiation into cardiomyocytic and endothelial phenotypes.
- Evaluation of angiogenic and antiapoptotic growth factor production.
Main Results:
- Adipose tissue contains cells capable of differentiating into cardiomyocytic and endothelial lineages.
- These cells secrete angiogenic and antiapoptotic factors.
- Preclinical studies in large animals support this therapeutic potential.
Conclusions:
- Human adipose tissue is a viable source for stem cells with cardiac regenerative potential.
- Adipose-derived cells offer promise for treating ischemic heart conditions.
- Further research supports adipose tissue as a source for cardiac cell therapy.
Abstract:
Recent preclinical and clinical studies have suggested that adult stem cells have the ability to promote the retention or restoration of cardiac function in acute and chronic ischemia. Published clinical studies have used autologous donor cells, including skeletal muscle myoblasts, cultured peripheral blood cells, or bone marrow cells. However, our research and that of others indicates that human adipose tissue is an alternative source of cells with potential for cardiac cell therapy. These findings include the presence of cells within adipose tissue that can differentiate into cells expressing a cardiomyocytic or endothelial phenotype, as well as angiogenic and antiapoptotic growth factors. This potential is supported by preclinical studies in large animals.
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