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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

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Published on: April 28, 2019

[Clinical and epidemiological aspects of the dengue epidemic in Recife, PE, 2002]

Demetrius Montenegro1, Heloisa Ramos Lacerda, Tereza Maciel Lira

  • 1Diretoria de Vigilância Epidemiológica, Secretaria Municipal de Saúde, Recife, PE.

Revista Da Sociedade Brasileira De Medicina Tropical
|February 28, 2006
PubMed

Insights

This study on the 2002 Recife dengue epidemic found Dengue serotype 3 (Den-3) predominated. Vascular collapse (shock) was the primary cause of death in most fatal cases, often without major bleeding.

Area of Science:

  • Virology
  • Epidemiology
  • Pathology

Context:

  • The 2002 dengue epidemic in Recife, Brazil, resulted in significant mortality.
  • Understanding the clinical and pathological features of fatal dengue cases is crucial for public health interventions.

Purpose:

  • To analyze the clinical, laboratorial, and necropsy findings of 14 patients who died during the 2002 dengue epidemic in Recife.
  • To identify the predominant dengue serotype and the main causes of death.

Summary:

  • Dengue serotype 3 (Den-3) was detected in 76.3% of fatal cases.
  • Deaths predominantly occurred in men over 20 years old, around the 11th day of illness, often in private hospitals.
  • Vascular collapse (shock) was observed in 85.7% of cases and identified as the main cause of death, irrespective of major bleeding. Hepatitis with elevated transaminases was common, usually without jaundice.
  • Average hematocrit was 40.7% and platelet count was 56,313 p/mm3.

Impact:

  • Findings highlight vascular collapse as a critical factor in dengue mortality, emphasizing the need for early shock management strategies.
  • The study provides valuable data for refining clinical guidelines and public health responses to severe dengue hemorrhagic fever.

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