Related Experiment Video
Updated: Aug 11, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
[Measurement of peripapillary nerve fiber layer thickness at different distances from the optic nerve head with OCT]
A G Böhm1, E Schmidt, M Müller-Holz
1Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Carl Gustav Carus, Dresden. boehm@uniklinikum-dresden.de
Purpose:
The aim of this study was to assess which distance to the optic nerve head is most favorable for circular measurements of retinal nerve fiber layer thickness (RNFLT) with OCT to detect differences between glaucoma and normal subjects.
Methods:
A total of 98 eyes of 67 subjects (normal subjects and POAG patients) were examined by Stratus OCT (Zeiss, Model 3000, Software Version 2.0). Images were scanned in the "proportional circle" mode and analyzed with the "RNFL thickness analysis" protocol. For statistical analysis the Friedman test and the Mann-Whitney U test with Bonferroni correction were used.
Results:
For 23 normal and 19 eyes of POAG patients a complete set of scans could be analyzed by the OCT software. RNFLT was statistically significantly different in scan diameters in both groups (P=0.000). Differences between the groups were statistically significant for the 1.0-fold (P=0.003), for the 1.4-fold (P=0.01), and for the 1.8-fold (P=0.002) disc diameter.
Conclusion:
Circular scans with a 1-fold and with a 1.8-fold disc diameter seem to be able to differentiate best between glaucoma and normal subjects.
